Sexual Side Effects of SSRIs: What You Need to Know

When you start taking an SSRI, a class of antidepressants that increase serotonin levels in the brain to improve mood. Also known as selective serotonin reuptake inhibitors, these drugs are among the most prescribed treatments for depression and anxiety. But for many people, the relief in mood comes with an unexpected cost: sexual side effects of SSRIs. These aren’t rare glitches—they’re common, often underreported, and sometimes long-lasting.

Think of your brain’s serotonin system like a dimmer switch. SSRIs turn it up to help with sadness or panic, but that same boost can mess with the nerves and hormones that control sexual response. You might notice less interest in sex, trouble getting or keeping an erection, delayed or absent orgasm, or even numbness in the genitals. These aren’t just "in your head"—they’re real biological changes. Studies show up to 70% of people on SSRIs experience some form of sexual dysfunction, yet many never tell their doctor because they feel embarrassed or assume it’s normal. It’s not. And it doesn’t have to be permanent.

The good news? You have options. Some people find relief by switching to an SSRI with fewer sexual side effects, like bupropion or vortioxetine. Others use dose adjustments, timing changes (like taking the pill in the morning), or add-on treatments like low-dose buspirone. Even non-drug approaches—like therapy, mindfulness, or couples counseling—can help rebuild intimacy. And if you’re thinking about stopping your SSRI because of this, don’t do it alone. Abruptly quitting can trigger withdrawal symptoms like dizziness, brain zaps, or mood crashes. There’s a safer way.

This collection of articles doesn’t just list problems. It gives you real tools: how to talk to your doctor without shame, what alternatives actually work, how to spot when side effects are more than just annoying, and what to do if the problem sticks around after you stop the drug. You’ll find insights from people who’ve been there, and science that cuts through the noise. No fluff. No jargon. Just what you need to take back control.

8 Dec 2025
by Michael Brown
9 Comments

Managing SSRI Sexual Dysfunction: Dose Changes, Switches, and Adjuncts

SSRI-induced sexual dysfunction affects 35-70% of users. Learn how dose changes, switching antidepressants, and adding bupropion can restore sexual function without sacrificing depression treatment.