SSRI Sexual Dysfunction: What It Is, Why It Happens, and What You Can Do

When you start taking an SSRI, a class of antidepressants that increase serotonin levels in the brain to improve mood. Also known as selective serotonin reuptake inhibitors, these drugs are among the most prescribed treatments for depression and anxiety. But for many people, the relief they get from their mood comes with an unwanted trade-off: SSRI sexual dysfunction, a group of sexual side effects including reduced libido, delayed orgasm, or inability to achieve erection or arousal. It’s not rare—it affects up to 70% of users. And yet, most patients never bring it up with their doctor, and many doctors don’t ask. That’s a problem, because this isn’t just about sex. It’s about quality of life, mental health, and sticking with treatment.

This isn’t a side effect you can just ignore. Serotonin, a brain chemical that helps regulate mood, sleep, and sexual response is the very thing these drugs boost to help you feel better. But too much serotonin in certain pathways can shut down sexual function. It’s like turning up the volume on your mood radio—only to mute the music you actually want to hear. And while some people adjust over time, others don’t. For them, the problem doesn’t fade. It sticks around. And if you’re already struggling with depression, adding sexual frustration on top can make things worse, not better.

What’s surprising is how many options exist to fix this without stopping your antidepressant. Some people switch to a different SSRI, like bupropion or vortioxetine, which have lower rates of sexual side effects. Others add a low-dose medication like bupropion or sildenafil to counteract the problem. Even small changes—timing your dose, adjusting when you have sex, or trying non-drug approaches like counseling—can make a real difference. The key is talking about it. You’re not alone. And you don’t have to suffer in silence.

The posts below cover real stories and science-backed solutions. You’ll find what works, what doesn’t, and how to talk to your doctor without feeling awkward. From drug interactions that make it worse (like mixing SSRIs with St. John’s Wort) to practical tips for managing symptoms, this collection gives you the tools to take back control—without giving up your mental health treatment.

8 Dec 2025
by Michael Brown
9 Comments

Managing SSRI Sexual Dysfunction: Dose Changes, Switches, and Adjuncts

SSRI-induced sexual dysfunction affects 35-70% of users. Learn how dose changes, switching antidepressants, and adding bupropion can restore sexual function without sacrificing depression treatment.